The San Francisco 49ers running back is questionable with a sprained foot, but per ESPN’s Adam Schefter: he “plans to play” and Guerendo has said he feels good.

Three of last week’s top pickups — Isaac Guerendo (26.8 points), Adam Thielen (19.2) and Juwan Johnson (15) — won matchups in Week 14. Let’s try to hit on all four must-adds for Week 15, which omit the previously mentioned Thielen or the obvious Zach Charbonnet, who are priorities.

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, and Thursday will be no

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian McCaffrey and Jordan Mason are both on injured reserve, leaving rookie Isaac Guerendo as the top back.

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the remainder of the regular season. Well, Guerendo suffered an injury of his own last week and is in danger of missing a Thursday night matchup with the Rams.

Sep 29, 2024; Santa Clara, California, USA; San Francisco 49ers running back Isaac Guerendo (31) warms up before the game against the New England Patriots at Levi’s Stadium. Mandatory Credit: Sergio Estrada-Imagn Images Now you need Guerendo in case Mason goes down.

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest on his status.