SportsLine's team of Vegas experts and its proven model and AI PickBot get you ready for Week 15 NFL betting sites

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Lamar Jackson and the Baltimore Ravens (8-5) take to the field at MetLife Stadium Sunday as greater than two touchdown favorites against the New York Giants (2-11). This is the largest spread of the weekend in the NFL. It is also the largest spread in favor of a Giants’ opponent for a New York home game since 1966.

SportsLine's advanced model has locked in its Week 15 NFL betting picks and football predictions from 10,000 simulations to tell you how to bet NFL games

The Detroit Lions (12-1) take an 11-game winning streak into a matchup with the Buffalo Bills (10-3) on Sunday, December 15, 2024 at Ford Field. Detroit is just 2.5-point favorite in the game.NFL

Buffalo and Detroit meet for one of the most entertaining matchups of the season and a potential Super Bowl preview.

The Detroit Lions will host the Buffalo Bills on Sunday during one of the most important games on the Week 15 NFL schedule. Detroit is sitting atop the NFC with a 12-1 record, while Buffalo is looking to bounce back from a 44-42 loss to the Rams.

There is a potential Super Bowl matchup on Sunday afternoon between the 10-3 Bills and the 12-1 Lions. The Bills are fighting for the second seed with the Steelers, who are also 10-3 but have a difficult schedule.

No game will be bigger than the potential Super Bowl preview between the Lions and Bills. Plus, the Steelers have a pivotal matchup on the road against the Eagles.

Week 15 offers a thrilling slate of games, but the headline matchup is the Detroit Lions hosting the Buffalo Bills. Both teams boast two of the league's best records, making this a potential Super Bowl preview.